Tuesday, 16 February 2016

Terminology associated with Glissandra's products!

Mitochondria, Glutathione, ATP production, Redox Cycling are terms often used in Glissandra's products!




Mitochondria, located within the cells are responsible for generating energy to the body and is important for optimal bodily function and cell health. 


Glutathione, is the body's "master" built in antioxidant system.


ATP production, is the cell's ability to store and supply the body with energy resources


Redox Cycling is the ability for the body to recycle glutathione.









Glissandra™ Skincare Inc. 305-5811 Cooney Road Richmond, BC Canada, V6X3M1

Skin protection with Glissandra. Protect against damaging rays.

Glissandra's proprietary ingredient Glissandrin helps to ward off the effects of UV and infrared damaging rays also known as solar-irradiation which induces oxidative injury to skin tissues and skin cells.

Glissandra makes UV protection simple and effective with their skincare and supplement product line.

Rain or Shine, Glissandra products are there to minimize the damaging effects of the sun.


Glissandra™ Skincare Inc. 305-5811 Cooney Road Richmond, BC Canada, V6X3M1

Glissandrin versus Schisandrin by Glissandra Inc.


What is the differance between Glissandrin and
 Schisandrin?


Schisandrin is the chemistry located within the Schissandra Berry which is harvested from the North East part of China and used in Glissandra's products. Schissandrin's are known to contain anit-aging properties and have been utilized in TCM (traditional Chinese Medicine) for centuries. Considered a herb, the schissandra berry has been extensively studied, researched and documented in scientific journals.

Glissandrin, is Glissandra's propreitary ingredient consisting of a suite of Schisandrins such as vitamins A, B, C and -B. A labour of love, Glissandrin has been formulated to deal with the root cause of aging (mitochondria) and change cellular reactions to anti-oxidants (free radicals).


Glissandra's products deal with the root cause of aging rather than masking the effects.




Glissandra™ Skincare Inc. 305-5811 Cooney Road Richmond, BC Canada, V6X3M1

Tuesday, 2 February 2016

UNCOUPLING FACTOR/PROTEINS


WHAT ARE UNCOUPLING PROTEINS?

Uncoupling proteins are transporters, present in the mitochondrial inner membranes that utilize the spread of protons (positive electoral atoms) to reduce the amount of oxidant damage generated through ATP production (transport of energy for metabolism).  Energy production is used to generate heat instead of producing energy for metabolism of cells.[i] The hypothesis that uncoupling proteins of the mitochondrial membrane can reduce body adiposity (fat) and that lower metabolic weight gain.[ii]




Note: There are 5 different types of uncoupling proteins each with their own functions and chemistry.[iii]  The subject of uncoupling proteins is scientifically advanced. The above statement is a shortened version of the extensive science behind the process. To research uncoupling proteins please refer to scientific journals as your source. 



[i] http://www.ncbi.nlm.nih.gov/pubmed/11484071
[ii] http://ww.ncbi.nlm.nih.gov/pubmed/11484071
[iii] http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=207

Alzheimers, Huntington's, ALS and Parkinson's Neurodegenerative Diseases


Can brain degeneration be combatted?


Neurodegenerative Diseases


Brain Degenerative Diseases such as Huntington’s, Parkinson’s, Amyotrophic Lateral Sclerosis (ALS) and all forms of dementia including Alzheimer’s are all classified as diseases affected by brain. Degenerative brain diseases have an enormous impact on our aging society. Alzheimer's disease progressively robs its victims of their memory. Parkinson's disease leads to impairments in movement. Frontotemporal (occurring the front area of the brain) dementia causes bewildering changes in a person's thoughts and behaviour. Huntington's disease painstakingly deprives a person of their ability to walk, talk, think and reason, often as early as in their mid-30s and 40s. In all of these degenerative brain diseases, the time from the onset of symptoms until death can be as many as ten or twenty years, with many sufferers' lives characterised by a total loss of independence in their final years.[i]




Over production of ROS (oxidative stress) is a central feature of all neurodegenerative disorders.[ii] There is strong evidence that mitochondrial dysfunction and oxidative stress plays a  role in neurodegenerative disease pathogenesis, including  four of the more well-known diseases Alzheimer's, Parkinson's, Huntington's, and Amyotrophic lateral sclerosis (ALS).[iii]

Alzheimer's Disease

Alzheimer's disease is characterised by loss of neurons (specialized nerve cells) and synapses (nerve cell signaling) in the cerebral cortex (outer layer of frontal part of the brain playing a role in consciousness) and certain subcortical regions (functional, connective and developmental areas of the brain). This loss results in gross atrophy (shrinkage) of affected areas of the brain.

Parkinson's Disease

Parkinson's disease is the second most common neurodegenerative disorder. Parkinson's disease is a degenerative disorder of the central nervous system. It results from the death of dopamine-generating (neuro-transmitter that send signals to other nerve cells).


Huntington's Disease


Huntington’s Disease causes astrogliosis (decrease of brain and spinal cord cells) and loss of neurons (specialized nerve cells).  Areas of the brain are affected according to their structure and the types of neurons they contain, reducing in size as they cumulatively  lose cells.


Amyotrophic Lateral Sclerosis (ALS) also commonly known as Lou Gehrig’s Disease


Amyotrophic lateral sclerosis (ALS or Lou Gehrig’s Disease) is a disease in which motor neurons are selectively targeted for degeneration affecting movement and speech.


Aging and Neurodegeneration


The greatest risk factor for neurodegenerative diseases is aging. Mitochondrial DNA mutations as well as oxidative stress both contribute to aging.  Many of these diseases are late-onset, meaning there is some factors that change as a person ages for each disease. One constant factor is that in each disease, neurons (specialized nerve cells) gradually lose function as the disease progresses with age.[iv]  Cell health is imperative to mitigate the damaging effects associated with degenerative disease.







[i] http://www.neuroscience.cam.ac.uk/research/cameos/DegeneratingBrain.php
[ii] https://en.wikipedia.org/wiki/Neurodegeneration
[iii] https://www.ncbi.nlm.nih.gov/pubmed/17051205
[iv] https://www.ncbi.nlm.nih.gov/pubmed/17051205

Tuesday, 26 January 2016

Schisandrin B can help with damaging effects of UV exposure.

Exposure to UV (ultraviolet) radiation can have an impact on health. Sunlight is the major cause of UV exposure.  Although sunlight has some benefits to the body such as the absorption of vitamin D and aiding in the treatment of specific medical procedures, care must be taken to avoid unnecessary exposure.

Free radicals (such as short wave UV radiation from the sun) alter the structure of the body’s cells eventually leading to cell death. Risks associated with overexposure to UV light are erythema (redness and inflammation) premature aging, eye damage, skin cancer/s and weakening of the immune system.


“Excessive exposure to ultraviolet radiation is associated with different types of skin cancer, sunburn, accelerated skin aging, as well as cataracts and other eye diseases. The severity of the effect depends on the wavelength intensity and duration of exposure”[1] 

Schisandrin B can be a protective barrier to UV exposure. Schisandrin B, a key component of Glissandrin™, can protect against solar irradiation-induced oxidative injury in skin tissue and skin cells, according to recent research findings from the laboratory of Dr. Robert Ko at the Hong Kong University of Science and Technology.[2]

As the largest organ in the human body, the skin serves as an effective barrier for protecting against various external threats. This includes exposure to harmful solar irradiation – particularly UV and infrared rays-which research has shown to be a major cause of skin aging. Although human skin tissue possesses non-enzymatic and enzymatic antioxidant defense systems (built in anti-oxidant eradication processes) to cope with the increased oxidative stress caused by solar light radiation, long-term exposure or overexposure to solar light can overwhelm the antioxidant system.[3] When the antioxidant system is taxed, cell death occurs which leads to aging.


What if there was a way to enhance the skin’s natural antioxidant defenses to prevent photo-aging entirely? Schisandrin B (Sch B) is able to do just that, ushering in a new era in UV protective skincare. Schisandrin B is derived from the Schisandra fruit, an herb commonly used in Traditional Chinese Medicine (TCM). This naturally occurring herbal ingredient has been found to produce tissue non-specific protection against oxidative injury by enhancing cellular and mitochondrial glutathione antioxidant status in the heart, liver, kidney, and brain.[4]



The countries with the highest rates of skin cancers may surprise you


The top three countries with the highest rates of skin cancer and ranked per death/100,000 people are New Zealand, Australia and Slovenia. Often, these individuals also are diagnosed with melanoma which is the most virulent form of skin cancer. Kiwi's (New Zealander's) and Aussie's (Australians) are sun loving nations with residents being approximately 13 more times likely to develop skin carcinomas.

The KEY in preventing skin damage is to take precautions such as limiting over excessive sun exposure, covering up when required and the constant application of UV protection products.  Another way to protect the skin from UV damage is to provide a protective barrier using Shisandrin B based products.


More information on Schisandrin B can be found at these independent websites:
• National Institutes of Health (http://www.nih.gov/)
• Natural Medicines https://naturalmedicines.therapeuticresearch.com (formerly National Standards)




[1] https://www.ccohs.ca/oshanswers/phys_agents/ultravioletradiation.html
[2] http://www.glissandra.com/clientinc/uploadProtectiveSkincare.pdf
[3] http://www.glissandra.com/clientinc/uploadProtectiveSkincare.pdf
[4] www.glissandra.com/clientinc/uploadProtectiveSkincare.pdf